Kisspeptin-10

Kisspeptin is an essential neuropeptide hormone that plays a critical role in reproductive health by activating the KISS1R (GPR54) receptor. This stimulation triggers the release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus, which then drives the secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the pituitary. These hormones are central to ovulation, oocyte maturation, and spermatogenesis.

Kisspeptin is indispensable for the initiation and maintenance of puberty and ongoing fertility. In clinical applications, it’s being explored for fertility enhancement protocols, assisted reproductive technologies (ART) such as in vitro fertilization (IVF), and the treatment of certain forms of infertility.

By modulating the hypothalamic-pituitary-gonadal (HPG) axis at its root, Kisspeptin offers a more physiologic approach to fertility restoration compared to direct hormone replacement.

• Stimulates natural GnRH release for optimal reproductive hormone function
• Supports fertility in both men and women
• Promotes oocyte maturation and ovulation
• Enhances spermatogenesis and testicular function
• May aid in cases of hypogonadotropic hypogonadism
• Potential role in IVF protocols to improve egg quality and timing

Kisspeptin is primarily used to support reproductive hormone balance, particularly for enhancing natural testosterone production and improving fertility in men and women.

While HCG mimics LH directly, Kisspeptin works higher up the hormonal chain, stimulating GnRH, which then promotes LH and FSH production—offering a more natural and potentially gentler approach.

Yes. By restoring proper hormone signaling and boosting testosterone, Kisspeptin may help increase sexual desire and performance.

Current studies show it to be well-tolerated, with a lower risk of desensitization compared to direct hormone injections. However, long-term use should be monitored by a healthcare provider.

Yes. Kisspeptin receptors are present in the brain, and research suggests it may have positive effects on emotional regulation, mood, and anxiety—making it a promising neurohormonal modulator.